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4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr]

Orotic acid

CAS: 65-86-1

Molecular Formula: C5H4N2O4

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4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr] - Names and Identifiers

Name Orotic acid
Synonyms Orotic acid
ai3-25478[qr]
acidoorotico[qr]
6-carboxyuracil[qr]
orotic acid anhydrous
acideorotique(french)[qr]
acidumoroticum(latin)[qr]
2,6-Dihydroxy-4-pyrimidinecarboxylic acid
orotic acid free acid anhydrous plant*cell cultur
1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid
4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-
4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr]
2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid~Uracil-4-carboxylic acid
CAS 65-86-1
EINECS 200-619-8
InChI InChI=1/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
InChIKey PXQPEWDEAKTCGB-UHFFFAOYSA-N

4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr] - Physico-chemical Properties

Molecular FormulaC5H4N2O4
Molar Mass156.1
Density1.6814 (rough estimate)
Melting Point≥300 °C
Boling Point280.29°C (rough estimate)
Water SolubilitySlightly soluble
Solubility It is difficult to dissolve in water (0.18%), the solubility in boiling water is 13%, very slightly soluble in alcohol and organic solvents, and insoluble in ether. Salt dissolution in case of alkali
AppearanceWhite crystalline powder
ColorWhite
Merck13,6942
BRN383901
pKapK1:1.8(+1);pK2:9.55(0) (25°C)
Storage ConditionSealed in dry,Room Temperature
StabilityStable. Incompatible with strong oxidizing agents.
SensitiveMoisture proof, moisture proof and mildew proof
Refractive Index1.4800 (estimate)
MDLMFCD00006027
Physical and Chemical PropertiesMelting Point:>300°C
chemical properties
white crystalline powder.
UseMainly used in daily cosmetics and medicine, nucleic acid, biological research, medicine for the yellow liver medicine, heart disease drugs. Vitamins. Mainly used in daily cosmetics and medicine, nucleic acid, biological research, medicine for the yellow liver medicine, heart disease drugs, suitable for hyperuricemia, hypercholesterolemia, chronic hepatitis, liver cirrhosis. It can also be used as anti-anemia and nutrition agent.

4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr] - Risk and Safety

Risk CodesR22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S22 - Do not breathe dust.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany3
RTECSRM3180000
FLUKA BRAND F CODES10-21
TSCAYes
HS Code29335990
Hazard NoteHarmful
Toxicitypic-esc 1 g/L ZAPOAK12,583,72

4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr] - Upstream Downstream Industry

Downstream ProductsHydantoin

4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr] - Nature

Open Data Verified Data

semitransparent yellow-green liquid or milky-white solid, with slight milk fragrance and sweetness.

Last Update：2024-01-02 23:10:35

4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr] - Preparation Method

Open Data Verified Data

using milk, cream and skim milk as raw materials, the milk fat is first removed by centrifugation, and then the casein is coagulated, precipitated and separated by acid or rennet. Or dried whey powder. By the enzyme coagulation method, low inorganic salt content, high lactose content, low acidity, called sweet whey. With the appropriate acid to make skim milk after the condensation, some of the lactose into lactic acid, higher acidity, called acid whey.

Last Update：2022-01-01 11:16:32

4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr] - Use

Open Data Verified Data

This product can be used as a tissue improver, molding aids, processing aids, nutritional supplements, emulsifiers and gelling agents, widely used in meat products, baked products, cold drinks, beverages, dairy products, in pasta products and flavoring.

Last Update：2022-01-01 11:16:33

4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr] - Reference Information

NIST chemical information information provided by: webbook.nist.gov (external link)
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
Introduction Orotic acid is a substance naturally produced by the human intestinal flora. This acid is also called vitamin B13 or pyrimidinic acid. It is not actually a vitamin, but it was added to the diet of laboratory animals in the 1960s to this category. Added to food can promote heart health and show some vitamin-like benefits.
application field orotic acid, also known as vitamin B13, is a nutrient. In the field of medicine, orotic acid and its derivatives have a good effect on icteric hepatitis, fatty liver, acute and chronic hepatitis. As a nutritional cosmetic matrix, it can be well absorbed by the skin, promote cell metabolism, and significantly inhibit skin aging. The application of orotic acid in food and life science fields.
method of production whey is produced as a by-product of the cheese industry, is a clear liquid or slurry that is separated from the curd from which cheese and casein are made. Whey content in milk reached 80% ~ 90%, containing 50% of raw milk nutrients. The sweet whey pH of the by-products obtained from the production of hard and semi-hard, soft cheese and rennet casein is between 5.9 and 6.4. The pH of the acid whey obtained from the production of casein by mineral acid precipitation is 4.3 to 4.6.

orotic acid is obtained from diethyl oxalate by condensation with acetic acid and cyclization with urea to obtain 5-ethoxycarbonylmethylidenehydantoin, followed by ring extension and acid analysis.
physiological functions and effects The main function of orotic acid is to metabolize folic acid together with vitamin B12. Rich orotic acid helps to replace vitamin B12, although not completely replaced, but can reduce the damage of vitamin B12 deficiency. This acid is also used in cosmetics, pharmaceuticals, and animal feeding supplements. It is also widely used in bodybuilding competitions around the world because it is able to increase the amount of adenosine triphosphate (the body's main source of energy) secreted. Orotic acid does this by acting as an initial form of pyrophosphate, which is then used for pyrimidine synthesis. The greater the amount of pyrophosphate in the body, the more adenosine triphosphate can be produced.
orotic aciduria orotic aciduria is a disorder of pyrimidine metabolism caused by deficiency of hereditary orotic phosphoribosyl transferase and orotic nucleoside phosphate decarboxylase, it is a rare autosomal recessive disease. No abnormality at birth, 2~6 months after birth began to gradually appear physical and mental development. With pale, blue sclera, strabismus, low muscle tension and splenomegaly, peripheral blood showed megaloblastic anemia, low white blood cells. Bone marrow examination: both erythrocytes and granulocytes exhibited changes of megaloblasts. The amount of orotic acid in urine increased up to 400 ~ 1400mg/24h (adult normal value is about 1~4mg/24h), and the urine showed obvious turbidity when it was slightly cold, with needle-like crystals inside; crystalline urine can sometimes cause obstruction of the urinary tract. Treatment with high-dose uracil (150mg/kg) daily can quickly relieve anemia and orotic urine; The decrease in urinary orotic acid content suggests that during the pyrimidine biosynthesis process, orotic acid synthesis is regulated by a negative feedback mechanism.
both enzymes are simultaneously absent in hepatocytes, leukocytes and cultured fibroblasts of most patients. However, there have been reports of the lack of decarboxylase alone, and the clinical manifestations of such patients are not different from those who lack the above transferase and decarboxylase at the same time. Recent data suggest that orotate phosphoribosyl transferase and orotate nucleoside phosphate decarboxylase are simultaneously deficient because they share a common subunit and are under the control of a gene. At present, a variety of methods can be used to measure enzyme activity to assist in diagnosis and prenatal diagnosis.
store whey acid should be stored in a cool and dry place.
Use vitamins. Suitable for hyperuricemia, hypercholesterolemia, chronic hepatitis, cirrhosis. It can also be used as anti-anemia and nutrition agent. High dose can induce fatty liver. Acute hepatitis, leukemia, malignant tumor patients should not use.
orotic acid is a nutritional drug, also known as vitamin B13. The product was salified with 5-aminoimidazole-4-carboxamide at 90 ° C. To obtain aminominamide orotate (C9H10N6O5 · 2H2O,[2574-78-9]). Both drugs are hepatoprotective drugs.
It is mainly used in daily cosmetics and medicine, nucleic acid, biological research, medicine for the preparation of yellow liver drugs, heart disease drugs, etc.
Name: orotic acid Chinese synonyms: 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid; 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid; hot -4-formic acid; Uracil carboxylic acid; Uracil -6-carboxylic acid; Orotic acid; Vitamin B13; Anhydrous Orotic acid English name: Orotic acid English synonym: 1,2,3, 6-tetrahydroxy-2, 6-dioxo-4-pyrimidecarboxylicacid[qr];1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicaci;2,6-Dihydrox
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-09 02:00:10
4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr]
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Uracil Impurity 9 Monomer Visit Supplier Webpage Request for quotation
CAS: 65-86-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Orotic acid Request for quotation
CAS: 65-86-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Orotic acid Visit Supplier Webpage Request for quotation
CAS: 65-86-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Chengdu Baishixing Science and Technology Industry Co.,Ltd
Product Name: orotic acid Request for quotation
CAS: 65-86-1
Tel: 028-88536627
Email: gina@cd-bsx.com
Mobile: 13408677798
QQ: 1113114184 Click to send a QQ messageSend QQ message
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4-pyrimidinecarboxylicacid,1,2,3,6-tetrahydro-2,6-dioxo-[qr]
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